Best for: People who experience both motion sickness and migraines.
How it works: Roughly 12 million women who suffer from migraines also battle motion sickness. Experts suspect that the same part of the brainstem plays a role in both conditions, says Tylor. According to a 2011 study published in The Journal of Headache and Pain, rizatriptan—the only migraine medication specifically shown to reduce motion sickness—lessened motion-sickness symptoms in 87 percent of patients with migraines. The medication may fend off nausea by regulating serotonin, which is thought to be linked to migraine-related pain. Take the recommended dose about two hours before travel.
Good to know: Side effects can include dry mouth and drowsiness.