The Best Anti-Aging Products of All Time, According to Top Dermatologists

Skincare experts weigh in on the best anti-aging products.

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bottle of neutrogena hydro boost gel


Bad skincare habits are hard to beat. Maybe you were careless in your teens and 20s, regularly forgoing sunscreen, skipping washing your face at night, or frequenting tanning beds despite parental warnings. Now, the consequences of these choices are slowly showing up on your skin, taking the form of fine lines, wrinkles, brown spots, and other signs of aging.

Unfortunately, you can't turn back time, but you can take action to undo some of the damage—and prevent wrinkles from settling in deeper. One option is to use prescription-strength retinoids like a topical tretinoin cream, or turn to proven OTC products to restore your skin to its more youthful days (without losing all of the wisdom you've acquired along the way).

In an effort to track down the best anti-aging products, we asked some of the top board-certified pros around to share their skincare secrets and the products they swear by. While the following creams, serums, and sunscreens don't exactly boast magical powers, they're about as close as you can get to a genie in a bottle.

Avene A-Oxitive Antioxidant Water Cream

avene a-oxitive antioxidant water cream container


"Containing vitamins C and E, this antioxidant shields against free radicals and supports collagen production," says Lauren Fine, MD, a dermatologist at Chicago Cosmetic Surgery and Dermatology. "I love it because it hydrates, protects, and even layers beautifully under makeup, making it easy to use every day." Applying daily (to your face, neck, and décolleté) is key, she adds—that's when you'll really notice the anti-aging benefits this product can bring.

To buy: $44;

SkinMedica Total Defense + Repair

skinmedica spf 50 sunscreen container


The best preventative action you can take against aging is to always wear sunscreen. This one is a favorite of Sandy Marchese Johnson, MD, FAAD, who operates Johnson Dermatology in Fort Smith, Ark. "It's a broad-spectrum sunblock that protects against UVA, UVB, and infrared rays, and it also has skin antioxidants to repair damage," she says. A lightweight texture makes it easy to wear this cream with or without makeup, and it's also water resistant for up to 80 minutes.

To buy: $70;

SkinCeuticals C E Ferulic

skinceuticals vitamin c serum bottle


A darling product among dermatologists for years, this serum, while pricey, proves that a little goes a long way. The small, dark bottle is packed with 15-percent pure vitamin C, an antioxidant that helps with DNA repair. In turn, it brightens the skin and improves brown spots and fine lines, says Marisa Garshick, MD, FAAD, a dermatologist at MDCS Dermatology: Medical Dermatology & Cosmetic Surgery in New York.

"Because some formulations of vitamin C are unstable, not all vitamin C products are created equal," she says. "This one is formulated in a way that maintains its stability, giving way to great results." Once absorbed, vitamin C can remain effective for a minimum of 72 hours, so you don't need to use this serum every day.

To buy: $169;

Neutrogena Hydro Boost Water Gel

bottle of neutrogena hydro boost water gel


Proof that effective anti-aging products don't have to be expensive, this one can be found at most drug stores. It's made with hyaluronic acid, which hydrates and locks in moisture to keep your face looking smooth and soft. Think of it like a sponge for dry skin—it can absorb up to 1,000 times its weight in water. "Hyaluronic acid is an important part of our skin, and this product is the best one available to everyone," says Dr. Johnson. It's free of oils and dyes, plus the formula works for all skin types, and can be used for day and night.

To buy: $29;

SkinMedica Age Defense Retinol Complex

skinmedica age defense retinol complex bottle


"Must-have topical vitamin A products are the most studied and most effective anti-aging and anti-skin cancer topicals available," says Dr. Johnson. "The most accessible version is adapalene gel [like Differin], but I prefer this retinol because of the added ingredients to minimize scaling and allowing for good penetration into the skin." If you're sensitive to retinols, be careful with this one, as it has strong ingredients formulated to stimulate collagen production and faster cell turnover to minimize lines and wrinkles. Be aware that retinol not stored in a cool, dry place, away from sunlight, can be rendered inactive and therefore should be purged from your beauty collection.

To buy: $80;

Replenix Power of Three Cream

replenix power of three cream container


A long-time favorite in Dr. Bucay's practice, this cream is all about antioxidants. It contains 90 percent polyphenol isolates, the active ingredient in green tea, as well as reservatrol, the powerful antioxidant found in red wine. Both ingredients combine to offer strong anti-inflammatory benefits without oil or parabens, says Dr. Bucay, making it her go-to recommendation for even sensitive or redness-prone skin. "I recommend it for any skin type, although it's especially helpful for skin that needs a little help tolerating retinoids," she says.

To buy: $101;

RoC Retinol Correxion Deep Wrinkle Night Cream

RoC retinol correxion deep wrinkle night cream inside packaging


Another product that's easy to find at a drug store, "this tried-and-true retinol is great for someone who wants to get started with retinol or who has sensitive skin," says Dr. Garshick. Apply a dab before you go to sleep—nighttime is when your skin is most receptive to repair—to help reduce the look of fine lines and deep wrinkles, and you should notice results within about three months.

To buy: $20;

CeraVe SA Lotion

bottle of cerave sa lotion for rough skin


Anti-aging efforts are often concentrated on your face, but it's important to incorporate full-body products in your routine as well, says Dr. Johnson. "My favorite over-the-counter product is CereVe—it contains salicylic acid and lactic acid, which are not as [effective] as retinol but good at minimizing wrinkles and brown spots," she notes. The rich texture of this fragrance- and dye-free lotion makes it ideal for soothing flaky, dry skin common in winter, and it can also be used to treat Psoriasis-prone skin.

To buy: $15;

TIZO Photoceutical AM Replenish

TIZO photoceutical AM replenish tube next to cardboard packaging


"This is a great option for someone who wants to keep their morning skincare routine simple," says Vivian Bucay, MD, FAAD, dermatologist at Bucay Center for Dermatology and Aesthetics in San Antonio. "The formulation is oil-, paraben-, dye- and fragrance-free, and I like TiZO sunscreens because they are mineral-only sunscreens, which are less sensitizing and more stable than their chemical sunscreen counterparts."

With an SPF of 40, this one fights UV rays while feeling light on your skin and giving you a healthy glow. It contains cermides to maintain the skin's lipid barrier (i.e., keeps moisture in), and vitamins C and E to help neutralize free radicals, says Dr. Bucay.

To buy: $48;

Good Science Beauty 005-Fi Skin Firming Cream

good science beauty skin firming cream bottle next to packaging


When it comes to applying anti-aging products, don't forget about the skin that's right below your face. "The neck tends to be neglected and is a common area of concern for many people, especially in the era of 'tech neck,'" says Dr. Garshick.

"Additionally, we often focus attention on the surface of the skin, but what is also important is keeping the skin tight and youthful, which requires maintaining our balance of elastin and collagen," she adds. Her favorite product for accomplishing exactly that is this firming cream, which can be applied to both face and neck, and has ingredients like barley extract to improve elasticity.

To buy: $78;

Replenix RetinolForte 1x Serum

replenix retinol forte treatment serum pump bottle


"The best anti-aging products of all time remain the retinoids, which increase collagen and elastin tissue formation as well as strengthen the epidermal barrier," says Neil S. Sadick, MD, clinical professor of dermatology at Weill Cornell Medical College in New York.

This pharmaceutical-grade serum is his top pick for maximizing benefits, as it contains retinol that works with green-tea polyphenols to diminish signs of aging and reduce the appearance of age spots. It's available in multiple strengths, ranging from sensitive skin to advance treatment.

To buy: $15;

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  1. Juncan AM, Moisă DG, Santini A, et al. Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals. Molecules. 2021;26(15):4429. doi:10.3390/molecules26154429

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