The Route: Coastal Highway 1, from Fort Lauderdale to the Florida Keys, gives you major ocean views and access to the Biscayne Nature Center, the Dolphin Research Center, John Pennekamp Coral Reef State Park, and kayaking off of Big Pine Key. The food stops―Cuban sandwiches and coffee in Miami’s Little Havana neighborhood, seafood in the Keys―are unbeatable.

 The Route: Columbus, Indiana, to New Harmony, Indiana, via mostly state highways, offers gorgeous scenery (national forest, the Wabash River), friendly and inviting small towns, numerous covered bridges, and attractions like Abraham Lincoln’s boyhood home.

 The Route: The Wyoming loop of US 89 and Wyoming State Highway 120 (WY 120) meanders past bison, moose, elk, and lush forest, leading you to Grand Teton National Park and eventually Yellowstone National Park. Stop for a hike whenever your legs get restless, and in Shoshoni, slip into the Yellowstone Drug Store for the best milk shakes ever.