For stain-removal purposes, if the care label on the spotted garment says "Dry Clean Only," you should consider it non-washable. There's a little more leeway with everyday laundering. Rayon and cashmere, for instance, may often be safely hand washed, says Herb Barndt, a textiles professor at Philadelphia University. But Barndt advises testing the garment first, with a drop of water on an inconspicuous place, like the inside of a sleeve. No hot water, though — and no dryer.